Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896426 | 0.88 | PTGER4 (0.38) | KMT2ANUDT1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL28896253 | 0.85 | NUDT1 (0.38) | KMT2ANUDT1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL28896363 | 0.85 | ABCB1 (0.34) | NUDT1PTGER4SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1536739 | 0.82 | TSHR (0.45) | KMT2ANUDT1PTGER4SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25312311 | 0.81 | TSHR (0.44) | KMT2ANUDT1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL29211235 | 0.80 | AAK1 (0.32) | NUDT1PTGER4SMN1; SMN2KDM4EMAPT | |
| SCHEMBL29211251 | 0.79 | SMN1; SMN2 (0.36) | KMT2ASMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL29211256 | 0.78 | ALDH1A1 (0.37) | KMT2ASMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL28896617 | 0.77 | KMT2A (0.34) | KMT2ANUDT1PTGER4SMN1; SMN2ALDH1A1 | |
| SCHEMBL28896378 | 0.75 | ALDH1A1 (0.40) | KMT2ANUDT1PTGER4ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |