Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 7/20 | 0.45 |
| ▸ | THRB | P10828 | 7/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30345304 | 1.00 | EGLN1 (0.50) | EGLN1KDM4CCASRTHRATHRB | |
| SCHEMBL30345445 | 0.88 | HDAC3 (0.53) | EGLN1KDM4CFFAR1FTORAB9A | |
| SCHEMBL28446135 | 0.88 | HDAC3 (0.53) | EGLN1KDM4CFFAR1FTORAB9A | |
| SCHEMBL30345516 | 0.86 | EGLN1 (0.48) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL28449008 | 0.86 | EGLN1 (0.48) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL30345507 | 0.85 | EGLN1 (0.50) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL28442664 | 0.85 | EGLN1 (0.50) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL30345395 | 0.84 | HDAC3 (0.50) | EGLN1 | |
| SCHEMBL28448361 | 0.84 | HDAC3 (0.50) | EGLN1 | |
| SCHEMBL28449287 | 0.83 | EGLN1 (0.52) | EGLN1THRATHRBBBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111559982-A | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2020-08-21 | — | — | CN | claimed |
| CN-111559982-B | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2023-04-07 | — | — | CN | disclosed |
| CN-111559982-A | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2020-08-21 | — | — | CN | disclosed |