Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30345445 | 1.00 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC6EGLN1 | |
| SCHEMBL30345304 | 0.88 | EGLN1 (0.50) | EGLN1RAB9ANPSR1KDM4CFFAR1 | |
| SCHEMBL28897243 | 0.88 | EGLN1 (0.50) | EGLN1RAB9ANPSR1KDM4CFFAR1 | |
| SCHEMBL30345395 | 0.87 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC6EGLN1 | |
| SCHEMBL28448361 | 0.87 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC6EGLN1 | |
| SCHEMBL28441539 | 0.84 | DGAT1 (0.49) | HDAC1EGLN1EGLN3RAB9AKDM5B | |
| SCHEMBL28442501 | 0.82 | EGLN1 (0.64) | EGLN1EGLN3 | |
| SCHEMBL30345480 | 0.82 | EGLN1 (0.64) | EGLN1EGLN3 | |
| SCHEMBL10493046 | 0.77 | ATM (0.59) | HDAC3HDAC1HDAC2HDAC6RAB9A | |
| SCHEMBL28449008 | 0.74 | EGLN1 (0.48) | EGLN1EPHX2FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111559982-A | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2020-08-21 | — | — | CN | claimed |
| CN-111559982-A | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2020-08-21 | — | — | CN | disclosed |