Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28898026 | 0.88 | SMN1; SMN2 (0.43) | NCOA1NCOA3HSD17B10KMT2AMEN1 | |
| SCHEMBL21830618 | 0.78 | NNMT (0.47) | NCOA1NCOA3TSHRKMT2AMEN1 | |
| SCHEMBL15881230 | 0.78 | NNMT (0.46) | TSHRHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL23089103 | 0.75 | NNMT (0.31) | KMT2AMEN1 | |
| SCHEMBL28876608 | 0.74 | ALDH1A1 (0.35) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9572460 | 0.73 | MEN1 (0.36) | KMT2AMEN1MKNK1MKNK2 | |
| SCHEMBL17559336 | 0.73 | TSHR (0.54) | NCOA1NCOA3TSHRHSD17B10KMT2A | |
| SCHEMBL23089282 | 0.72 | GRM4 (0.35) | HSD17B10KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL15527772 | 0.72 | LMNA (0.41) | NCOA1NCOA3TSHRHSD17B10KMT2A | |
| SCHEMBL28912500 | 0.71 | PLAU (0.33) | KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-111527078-A | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2020-08-11 | — | — | CN | disclosed |