Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28455465 | 0.93 | HSD17B13 (0.44) | JAK2JAK3PTK2GPR119JAK1 | |
| SCHEMBL28457726 | 0.89 | PIK3CD (0.41) | JAK2JAK1BTK | |
| SCHEMBL28450201 | 0.85 | GPR119 (0.44) | JAK2JAK3PTK2GPR119KDM4E | |
| SCHEMBL25204156 | 0.82 | GPR119 (0.44) | JAK2JAK3PTK2GPR119MET | |
| SCHEMBL28456262 | 0.82 | PIK3CD (0.41) | JAK2JAK1BTK | |
| SCHEMBL28898961 | 0.82 | BTK (0.47) | BTKTLR8 | |
| SCHEMBL20135591 | 0.82 | GPR119 (0.50) | JAK2JAK3PTK2GPR119MET | |
| SCHEMBL17096981 | 0.81 | TDO2 (0.43) | GPR119 | |
| SCHEMBL25204635 | 0.80 | GPR119 (0.44) | JAK2JAK3PTK2GPR119TLR8 | |
| SCHEMBL20134846 | 0.80 | CNR1 (0.47) | GPR119MEN1HPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662232-B | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-08-02 | — | — | CN | disclosed |
| CN-111662232-A | Small molecule compound with 2H-indazole structure and synthesis and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |