Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805309 | 0.86 | HSD11B1 (0.44) | HSD11B1L3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL13593701 | 0.84 | EPHX2 (0.42) | L3MBTL1ALDH1A1GAAHTTLMNA | |
| SCHEMBL2885747 | 0.84 | L3MBTL1 (0.46) | HSD11B1L3MBTL1KDM4EALDH1A1PTGDR2 | |
| SCHEMBL2888387 | 0.84 | L3MBTL1 (0.48) | HSD11B1L3MBTL1KDM4EALDH1A1PTGDR2 | |
| SCHEMBL25278649 | 0.81 | CA1 (0.47) | HSD11B1L3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL16023210 | 0.81 | CA1 (0.47) | HSD11B1L3MBTL1KDM4EALDH1A1GAA | |
| SCHEMBL2881500 | 0.81 | L3MBTL1 (0.46) | HSD11B1L3MBTL1KDM4EALDH1A1MEN1 | |
| SCHEMBL30668758 | 0.81 | L3MBTL1 (0.46) | HSD11B1L3MBTL1KDM4EALDH1A1MEN1 | |
| SCHEMBL16967783 | 0.81 | KDM4E (0.51) | HSD11B1L3MBTL1KDM4EALDH1A1CYP2C9 | |
| SCHEMBL2882509 | 0.80 | L3MBTL1 (0.44) | HSD11B1L3MBTL1KDM4EALDH1A1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723347-B2 | Substituted phenylamino-pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-25 | — | — | US | disclosed |
| US-7723347-B2 | Substituted phenylamino-pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-25 | — | — | US | disclosed |
| US-7723347-B2 | Substituted phenylamino-pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-25 | — | — | US | disclosed |
| EP-1742945-B1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | BAYER SCHERING PHARMA AG (DE) | 2009-12-30 | — | — | EP | disclosed |
| US-7528146-B2 | Substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof | LANXESS DEUTSCHLAND GMBH (DE) | 2009-05-05 | — | — | US | disclosed |
| US-7528146-B2 | Substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof | LANXESS DEUTSCHLAND GMBH (DE) | 2009-05-05 | — | — | US | disclosed |
| US-7528146-B2 | Substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof | LANXESS DEUTSCHLAND GMBH (DE) | 2009-05-05 | — | — | US | disclosed |
| US-20080269268-A1 | Substituted Phenylamino-Pyrimidines | BAYER HEALTHCARE AG (DE) | 2008-10-30 | — | — | US | disclosed |
| US-20080269268-A1 | Substituted Phenylamino-Pyrimidines | BAYER HEALTHCARE AG (DE) | 2008-10-30 | — | — | US | disclosed |
| US-20080269268-A1 | Substituted Phenylamino-Pyrimidines | BAYER HEALTHCARE AG (DE) | 2008-10-30 | — | — | US | disclosed |
| EP-1742945-A1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | Bayer HealthCare AG (DE) | 2007-01-17 | — | — | EP | disclosed |
| EP-1671970-A1 | Substituted 1H-pyrrolo(2,3-b)pyridines and preparation thereof | Lanxess Deutschland GmbH (DE) | 2006-06-21 | — | — | EP | disclosed |
| US-20060128661-A1 | Novel substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof | LANXESS DEUTSCHLAND GMBH (DE) | 2006-06-15 | — | — | US | disclosed |
| WO-2005108397-A1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | BAYER HEALTHCARE AG (DE) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108397-A1 | SUBSTITUTED PHENYLAMINO-PYRIMIDINES | BAYER HEALTHCARE AG (DE) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269268-A1 | Substituted Phenylamino-Pyrimidines | TYMP, DPYD, HPRT1 | HSD11B1 4240/4885L3MBTL1 1807/4885KDM4E 2250/4885 |
| US-20060128661-A1 | Novel substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof | FARS2, FARSB, PYCR1 | HSD11B1 619/4885L3MBTL1 4764/4885KDM4E 2579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.