Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine SCHEMBL4081041 | 0.96 | — | — | |
| Pyrazine SCHEMBL8936652 | 0.96 | TSHR (0.50) | ALDH1A1TSHRPOLB | |
| Pyridine SCHEMBL5579148 | 0.83 | TSHR (0.56) | ALDH1A1TSHR | |
| Pyrazine SCHEMBL27594329 | 0.81 | MAPT (0.47) | ALDH1A1TSHR | |
| Pyrazine SCHEMBL28845759 | 0.79 | — | — | |
| Pyridine SCHEMBL8610477 | 0.79 | TSHR (0.60) | ALDH1A1TSHR | |
| Pyridine SCHEMBL28757618 | 0.79 | TSHR (0.60) | ALDH1A1TSHR | |
| Pyridine SCHEMBL8610474 | 0.79 | TSHR (0.60) | ALDH1A1TSHR | |
| Pyridine SCHEMBL180736 | 0.79 | — | — | |
| Pyridine SCHEMBL10950366 | 0.76 | TSHR (0.56) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747901-A | Method for selectively breaking C-N bond in melamine resin | 中国科学院山西煤炭化学研究所 | 2020-10-09 | — | — | CN | disclosed |