Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine SCHEMBL4081041 | 1.00 | — | — | |
| Pyrazine SCHEMBL28899285 | 0.96 | ALDH1A1 (0.46) | TSHRALDH1A1POLB | |
| Pyrazine SCHEMBL27594329 | 0.84 | MAPT (0.47) | TSHRALDH1A1 | |
| Pyrazine SCHEMBL28845759 | 0.82 | — | — | |
| Pyridine SCHEMBL8610477 | 0.82 | TSHR (0.60) | TSHRALDH1A1NAPRTTDP1 | |
| Pyridine SCHEMBL8610474 | 0.82 | TSHR (0.60) | TSHRALDH1A1NAPRTTDP1 | |
| Pyridine SCHEMBL28757618 | 0.82 | TSHR (0.60) | TSHRALDH1A1NAPRTTDP1 | |
| Pyridine SCHEMBL180736 | 0.82 | — | — | |
| Pyridine SCHEMBL10904050 | 0.79 | TSHR (0.56) | TSHRALDH1A1NAPRTTDP1 | |
| Pyridine SCHEMBL11518871 | 0.79 | TSHR (0.56) | TSHRALDH1A1NAPRTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1042333-C | 5, 6-disubstituted-3-picolyl ammonium halide compound and preparation method thereof | AMERICAN CYANAMID CO (US) | 1999-03-03 | — | — | CN | disclosed |
| CN-1190094-A | Process of 5-(substituted methyl)-2,3-pyridinedicarboxylic acids | AMERICAN CYANAMID CO (US) | 1998-08-12 | — | — | CN | disclosed |
| US-5545835-A | CHEMICAL INTERMEDIATES FOR PREPARATION OF SUBSTITUTED 2,3-PYRIDINEDICARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| US-5378843-A | Halogenation, quaternization | AMERICAN CYANAMID COMPANY (US) | 1995-01-03 | — | — | US | disclosed |
| US-5288866-A | Chemical intermediates in the preparation of purity herbicides | AMERICAN CYANAMID COMPANY (US) | 1994-02-22 | — | — | US | disclosed |