Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrazine SCHEMBL8936652 | 1.00 | TSHR (0.50) | — | |
| Pyrazine SCHEMBL28899285 | 0.96 | ALDH1A1 (0.46) | — | |
| Pyrazine SCHEMBL27594329 | 0.84 | MAPT (0.47) | — | |
| Pyrazine SCHEMBL28845759 | 0.82 | — | — | |
| Pyridine SCHEMBL8610477 | 0.82 | TSHR (0.60) | — | |
| Pyridine SCHEMBL8610474 | 0.82 | TSHR (0.60) | — | |
| Pyridine SCHEMBL28757618 | 0.82 | TSHR (0.60) | — | |
| Pyridine SCHEMBL180736 | 0.82 | — | — | |
| Pyridine SCHEMBL10904050 | 0.79 | TSHR (0.56) | — | |
| Pyridine SCHEMBL11518871 | 0.79 | TSHR (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5199861-A | — | — | None | — | — | JP | disclosed |
| CN-107074896-A | Electroluminescent Imidazoquinoxaline Carbene Metal Complexes | UDC 爱尔兰有限责任公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-105394805-B | Method for enabling carbon dioxide expanded tobacco to highlight sweet aroma style | 安徽中烟工业有限责任公司 | 2017-01-25 | — | — | CN | disclosed |
| US-20090215761-A1 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| EP-1874731-A4 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS INC (US) | 2009-08-05 | — | — | EP | disclosed |
| US-7402579-B2 | Quinobenzoxazine analogs and compositions | CYLENE PHARMACEUTICALS, INC. (US) | 2008-07-22 | — | — | US | disclosed |
| EP-1874731-A2 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | Cylene Pharmaceuticals, Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20060264634-A1 | Quinobenzoxazine analogs and methods of using thereof | CYLENE PHARMACEUTICALS, INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006113509-A2 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| JP-H05199861-A | SMOCKING COMPOSITION CONTAINING PYRAZINE ETHANOL SPICE RELEASING ADDITIVE | PHILIP MORRIS PROD INC | 1993-08-10 | — | — | JP | disclosed |