SCHEMBL28899663

SCHEMBL28899663

N=C(N)N(OC(F)F)C(=N)Nc1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
TP53 P04637 2/20 0.38
TSHR P16473 2/20 0.38
TAS2R38 P59533 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TYR P14679 1/20 0.38
GAA P10253 4/20 0.34
LMNA P02545 2/20 0.34
MAPT P10636 1/20 0.34
GFER P55789 1/20 0.34
POLB P06746 1/20 0.34
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
CYP2D6 P10635 1/20 0.34
SLC6A2 P23975 1/20 0.34
KMT2A Q03164 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
GRIN2B Q13224 1/20 0.34
GRIN2C Q14957 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28960082 0.79 ALDH1A1 (0.41) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL28899654 0.78 ALDH1A1 (0.38) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL14868313 0.69 TAS2R38 (0.45) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL1740828 0.68 ALDH1A1 (0.44) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL28899776 0.68 PHGDH (0.39) ALDH1A1TP53TSHRTAS2R38HSD17B10
Hydrochloric Acid SCHEMBL31696764 0.67 ALDH1A1 (0.42) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL28899747 0.66 KDM4E (0.44) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL28899664 0.66 ALDH1A1 (0.31) ALDH1A1
Phenylguanidine SCHEMBL256023 0.65 ALDH1A1 (0.58) ALDH1A1TP53TSHRTAS2R38HSD17B10
SCHEMBL28899642 0.65 ALDH1A1 (0.41) ALDH1A1TP53TSHRTAS2R38HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115414480-A Dianhydrogalactitol in combination with radiation for treatment of non-small cell lung cancer and glioblastoma multiforme 德玛医药 2022-12-02 CN disclosed