Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29670810 | 0.94 | KMT2A (0.39) | KMT2ATRPM8MMP2MMP9ADRA2C | |
| SCHEMBL4775104 | 0.86 | CPA3 (0.42) | KMT2ACYP2C19ALDH1A1GAAMEN1 | |
| SCHEMBL9814706 | 0.79 | KMT2A (0.40) | KMT2ATRPM8MMP2MMP9ADRA2C | |
| SCHEMBL11222161 | 0.75 | KMT2A (0.50) | KMT2AMMP2MMP9BLMPMP22 | |
| SCHEMBL11222164 | 0.75 | KMT2A (0.50) | KMT2AMMP2MMP9BLMPMP22 | |
| SCHEMBL9716679 | 0.74 | ADRA2C (0.50) | TRPM8MMP2MMP9ADRA2CF2 | |
| SCHEMBL15484293 | 0.74 | ADRA2C (0.50) | TRPM8MMP2MMP9ADRA2CF2 | |
| SCHEMBL9716684 | 0.74 | ADRA2C (0.50) | TRPM8MMP2MMP9ADRA2CF2 | |
| SCHEMBL8429588 | 0.73 | LMNA (0.39) | KMT2AMMP2MMP9ADRA2CBLM | |
| SCHEMBL8429495 | 0.73 | LMNA (0.39) | KMT2AMMP2MMP9ADRA2CBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111944778-A | Glutamine transaminase mutant and encoding gene and application thereof | 安徽医学高等专科学校 | 2020-11-17 | — | — | CN | disclosed |