Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.60 |
| ▸ | MDM4 | O15151 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28508740 | 0.91 | TP53 (0.52) | MDM2MDM4TP53HTTMAPK1 | |
| SCHEMBL28503127 | 0.89 | MDM4 (0.48) | MDM2MDM4TP53HTTSMN1; SMN2 | |
| SCHEMBL28506801 | 0.89 | TP53 (0.48) | MDM2MDM4TP53HTTMAPK1 | |
| SCHEMBL28492793 | 0.88 | MDM2 (0.62) | MDM2MDM4TP53HTTMAPK1 | |
| SCHEMBL28497091 | 0.86 | MDM4 (0.46) | MDM2MDM4TP53MAPK1SIRT2 | |
| SCHEMBL28495988 | 0.86 | HTR1A (0.51) | MDM2MDM4TP53SMN1; SMN2CYP11B2 | |
| SCHEMBL28504165 | 0.83 | MDM2 (0.52) | MDM2MDM4TP53HTTSMN1; SMN2 | |
| SCHEMBL28499278 | 0.83 | KDM4E (0.50) | MDM2MDM4TP53HTTMAPK1 | |
| SCHEMBL28508702 | 0.82 | MDM4 (0.44) | MDM2MDM4TP53SMN1; SMN2CYP11B1 | |
| SCHEMBL28503167 | 0.80 | TP53 (0.56) | MDM2MDM4TP53HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174937-B | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112174937-A | 3- (5-imidazolyl) indole compound and preparation method and application thereof | 南京农业大学 | 2021-01-05 | — | — | CN | disclosed |