Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30111779 | 1.00 | PDE10A (0.39) | PDE10AALDH1A1LMNAMAPK1KMT2A | |
| SCHEMBL30111776 | 0.85 | PDE10A (0.38) | PDE10AALDH1A1GPBAR1SMN1; SMN2HPGD | |
| SCHEMBL28906180 | 0.85 | PDE10A (0.38) | PDE10AALDH1A1GPBAR1SMN1; SMN2HPGD | |
| SCHEMBL19715541 | 0.78 | RAB9A (0.47) | ALDH1A1LMNAKMT2ARAB9AMEN1 | |
| SCHEMBL29272617 | 0.75 | SMN1; SMN2 (0.42) | ALDH1A1LMNAMAPK1KMT2ARAB9A | |
| SCHEMBL26133178 | 0.75 | CHRNB2 (0.38) | PDE10AALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL22230141 | 0.73 | CHRNB2 (0.40) | PDE10AALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL22230040 | 0.73 | PIK3CD (0.43) | PDE10AALDH1A1MAPK1KMT2ARAB9A | |
| SCHEMBL26098721 | 0.72 | CHRNB2 (0.38) | PDE10AALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL2952147 | 0.71 | KDM4E (0.50) | ALDH1A1MAPK1SMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149933-A1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-22 | — | — | EP | disclosed |
| CN-115461337-A | Novel triazolyl derivatives as GABA A alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |