Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30111776 | 1.00 | PDE10A (0.38) | PDE10APOLQGABRA1GPBAR1ALDH1A1 | |
| SCHEMBL30111779 | 0.85 | PDE10A (0.39) | PDE10AGPBAR1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28906165 | 0.85 | PDE10A (0.39) | PDE10AGPBAR1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL19715541 | 0.79 | RAB9A (0.47) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29272617 | 0.76 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2HTTHPGD | |
| SCHEMBL25464325 | 0.73 | ABL1 (0.38) | PDE10APOLQABL1BCRHTT | |
| SCHEMBL23384341 | 0.72 | ADCY10 (0.35) | ALDH1A1ABL1SMN1; SMN2HTTHPGD | |
| SCHEMBL30309354 | 0.72 | ADCY10 (0.35) | ALDH1A1ABL1SMN1; SMN2HTTHPGD | |
| SCHEMBL23362593 | 0.72 | KDM4E (0.37) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29757474 | 0.72 | KDM4E (0.37) | ALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461337-A | Novel triazolyl derivatives as GABA A alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | disclosed |