SCHEMBL28906362

SCHEMBL28906362

COc1ccc(C(=O)C=Cc2ccc(O)cc2C=O)cc1O

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CAPN1 P07384 2/20 0.66
CTSL P07711 5/20 0.62
CTSB P07858 5/20 0.62
TDP1 Q9NUW8 1/20 0.62
DPP4 P27487 4/20 0.61
SNCA P37840 1/20 0.59
CYP1A1 P04798 1/20 0.54
CYP1B1 Q16678 1/20 0.54
PTPN1 P18031 1/20 0.53
P4HB P07237 1/20 0.53
MAOB P27338 1/20 0.52
NR1H4 Q96RI1 1/20 0.52
PDE4A P27815 1/20 0.52
PDE4B Q07343 1/20 0.52
PDE4C Q08493 1/20 0.52
PDE4D Q08499 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28906356 0.90 CTSL (0.62) CAPN1CTSLCTSBTDP1DPP4
SCHEMBL28906370 0.83 CTSL (0.63) CAPN1CTSLCTSBTDP1DPP4
SCHEMBL2971621 0.81 CHRNA7 (0.67) CAPN1CTSLCTSBTDP1SNCA
SCHEMBL2971618 0.81 CHRNA7 (0.67) CAPN1CTSLCTSBTDP1SNCA
Echinatin SCHEMBL7193984 0.77 CTSL (1.00) CAPN1CTSLCTSBTDP1DPP4
Echinatin SCHEMBL618086 0.77 CTSL (1.00) CAPN1CTSLCTSBTDP1DPP4
Echinatin SCHEMBL29466900 0.77 CTSL (1.00) CAPN1CTSLCTSBTDP1DPP4
SCHEMBL31441462 0.76 DPP4 (1.00) DPP4SNCACYP1A1CYP1B1PTPN1
SCHEMBL28906376 0.75 CHRNA7 (0.73) TDP1NR1H4
SCHEMBL14290075 0.75 PDE4D (0.55) CAPN1TDP1PDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115304513-A Chalcone derivative with anti-inflammatory activity and synthesis method and application thereof 湖北科技学院 2022-11-08 CN disclosed