SCHEMBL28906356

SCHEMBL28906356

COc1cc(C(=O)C=Cc2ccc(O)cc2C=O)ccc1O

nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CTSL P07711 5/20 0.62
CTSB P07858 5/20 0.62
CAPN1 P07384 2/20 0.62
TDP1 Q9NUW8 1/20 0.62
DPP4 P27487 3/20 0.61
SNCA P37840 1/20 0.59
ABCG2 Q9UNQ0 1/20 0.58
CYP1A1 P04798 1/20 0.54
CYP1B1 Q16678 1/20 0.54
CHRNA7 P36544 1/20 0.53
PTPN1 P18031 1/20 0.53
TNFRSF1A P19438 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28906362 0.90 CAPN1 (0.66) CTSLCTSBCAPN1TDP1DPP4
SCHEMBL28906370 0.83 CTSL (0.63) CTSLCTSBCAPN1TDP1DPP4
SCHEMBL2971618 0.81 CHRNA7 (0.67) CTSLCTSBCAPN1TDP1SNCA
SCHEMBL2971621 0.81 CHRNA7 (0.67) CTSLCTSBCAPN1TDP1SNCA
SCHEMBL28906385 0.80 DPP4 (0.61) DPP4SNCAABCG2TNFRSF1A
SCHEMBL5599401 0.79 DPP4 (0.67) TDP1DPP4SNCAABCG2TNFRSF1A
SCHEMBL28906376 0.78 CHRNA7 (0.73) TDP1ABCG2CHRNA7
SCHEMBL5598905 0.77 CXCL12 (0.82) ABCG2
SCHEMBL5598901 0.77 CXCL12 (0.82) ABCG2
Echinatin SCHEMBL7193984 0.77 CTSL (1.00) CTSLCTSBCAPN1TDP1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115304513-A Chalcone derivative with anti-inflammatory activity and synthesis method and application thereof 湖北科技学院 2022-11-08 CN disclosed