Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1187421 | 0.86 | HSP90AA1 (0.61) | KDM4ELMNAMAPTALOX12L3MBTL1 | |
| SCHEMBL4301084 | 0.84 | HSP90AA1 (0.59) | KDM4ELMNAMAPTALOX12L3MBTL1 | |
| SCHEMBL23832886 | 0.83 | HTT (0.46) | KDM4EMAPTKMT2AHTTGAA | |
| SCHEMBL4012471 | 0.79 | KDM4E (0.42) | KDM4ELMNATSHRMAPTTP53 | |
| SCHEMBL13977561 | 0.79 | PSMD14 (0.56) | KDM4EMAPTHTTGAA | |
| SCHEMBL4522163 | 0.79 | PARP1 (0.41) | KDM4EL3MBTL1HTTMPI | |
| SCHEMBL5759312 | 0.79 | HTR1A (0.51) | KDM4ETSHRMAPTL3MBTL1HSP90AA1 | |
| SCHEMBL4496517 | 0.79 | NR4A2 (0.61) | KDM4ELMNAMAPTTP53ALOX12 | |
| SCHEMBL30492608 | 0.78 | CCR1 (0.45) | KDM4EMAPTL3MBTL1HSP90AA1NPC1 | |
| SCHEMBL25216590 | 0.78 | CCR1 (0.45) | KDM4EMAPTL3MBTL1HSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112300126-A | Heterocyclic DNA-PK inhibitors | 山东轩竹医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |