Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4894442 | 0.97 | PLA2G7 (0.34) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL27030667 | 0.97 | PLA2G7 (0.36) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL22070 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL28447867 | 0.94 | PLA2G7 (0.35) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL1685396 | 0.94 | PLA2G7 (0.35) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL21387942 | 0.92 | PLA2G7 (0.34) | PLA2G7CRBNBRD4BRD2PKM | |
| Formaldehyde SCHEMBL3082020 | 0.92 | PLA2G7 (0.34) | PLA2G7CRBNBRD4BRD2PKM | |
| Silver SCHEMBL27991638 | 0.84 | PKM (0.33) | PLA2G7PKM | |
| SCHEMBL4577654 | 0.79 | HDAC6 (0.35) | CRBNBRD4HDAC6ALDH1A1RECQL | |
| Phenol SCHEMBL11576606 | 0.77 | PLA2G7 (0.44) | PLA2G7BRD4KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443358-A | Method for controlling enzyme activity and tools related thereto | 凯米拉公司 | 2022-12-06 | — | — | CN | disclosed |