Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28907673 | 0.97 | PLA2G7 (0.35) | PLA2G7CRBNBRD4BRD2PKM | |
| Hydrochloric Acid SCHEMBL28447867 | 0.97 | PLA2G7 (0.35) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL27030667 | 0.95 | PLA2G7 (0.36) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL22070 | 0.95 | — | — | |
| SCHEMBL1685396 | 0.92 | PLA2G7 (0.35) | PLA2G7CRBNBRD4BRD2PKM | |
| Formaldehyde SCHEMBL3082020 | 0.90 | PLA2G7 (0.34) | PLA2G7CRBNBRD4BRD2PKM | |
| SCHEMBL21387942 | 0.90 | PLA2G7 (0.34) | PLA2G7CRBNBRD4BRD2PKM | |
| Silver SCHEMBL27991638 | 0.81 | PKM (0.33) | PLA2G7PKM | |
| SCHEMBL4577654 | 0.77 | HDAC6 (0.35) | CRBNBRD4HDAC6ALDH1A1RECQL | |
| Phenol SCHEMBL11576606 | 0.75 | PLA2G7 (0.44) | PLA2G7BRD4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080014289-A1 | Vehicle and method for treating and preventing acne vulgaris and exfoliating the skin hypohalous acids | LI JIANPING | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080014289-A1 | Vehicle and method for treating and preventing acne vulgaris and exfoliating the skin hypohalous acids | HAO2, HACL2, HAO1 | PLA2G7 2342/4885CRBN 3333/4885BRD4 3254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.