Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.45 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27942269 | 0.85 | MAOA (0.73) | MAOAMAOBLMNAMAPTTSHR | |
| SCHEMBL72752 | 0.85 | — | — | |
| Fluoride SCHEMBL27481173 | 0.83 | MAOA (0.70) | MAOAMAOBLMNAMAPTTSHR | |
| SCHEMBL28312718 | 0.81 | MAOA (0.61) | MAOAMAOBLMNAMAPTTSHR | |
| SCHEMBL28578951 | 0.79 | PARP15 (0.66) | MAOAMAOBLMNAMAPTTSHR | |
| SCHEMBL4446050 | 0.78 | MAOA (0.64) | MAOAMAOBLMNAMAPTTSHR | |
| Ammonia Solution, Strong SCHEMBL3939640 | 0.76 | MAOA (0.61) | MAOAMAOBLMNAMAPTTSHR | |
| SCHEMBL22086618 | 0.76 | MAOA (0.55) | MAOAMAOBLMNAMAPTTSHR | |
| SCHEMBL15902206 | 0.74 | LMNA (0.52) | LMNAIDO1CA12CA2CA3 | |
| SCHEMBL1348988 | 0.74 | MAOA (0.53) | MAOAMAOBLMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341363-A | Synthesis method of 4-chlorobenzenecyanoguanidine | 武汉科技大学 | 2021-02-09 | — | — | CN | disclosed |