Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2976365 | 0.83 | MAPT (0.50) | MAPTALDH1A1MAOBKMT2AMEN1 | |
| SCHEMBL2889768 | 0.83 | KDM4E (0.51) | MAPTKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL4986888 | 0.83 | MAPT (0.71) | MAPTKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL4981533 | 0.82 | SIRT5 (0.55) | MAPTKDM4EALDH1A1MAOBMAPK1 | |
| SCHEMBL4981482 | 0.81 | SIRT5 (0.53) | MAPTKDM4EALDH1A1MAOBKMT2A | |
| Diethylamine SCHEMBL2890896 | 0.81 | MAPT (0.59) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4983657 | 0.81 | KDM4E (0.66) | MAPTKDM4EALDH1A1MAOBKMT2A | |
| SCHEMBL4986148 | 0.80 | KDM4E (0.48) | MAPTKDM4EALDH1A1MAOBMAPK1 | |
| SCHEMBL4983931 | 0.80 | MAPT (0.53) | MAPTKDM4EKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL1665803 | 0.80 | MAPT (0.55) | MAPTKDM4EALDH1A1MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286197-A1 | Carboxamide Derivatives As Therapeutic Agents | TRANSTECH PHARMA, INC. | 2010-11-11 | — | — | US | disclosed |
| US-7776919-B2 | Carboxamide derivatives as therapeutic agents | TransTech Pharm, Inc. (US) | 2010-08-17 | — | — | US | disclosed |
| US-7423177-B2 | Carboxamide derivatives as therapeutic agents | TRANSTECH PHARMA, INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080119512-A1 | Carboxamide Derivatives as Therapeutic Agents | TRANSTECH PHARMA, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| EP-1377295-A4 | CARBOXAMIDE DERIVATIVES AS THERAPEUTIC AGENTS | TRANSTECH PHARMA INC (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1377295-A2 | CARBOXAMIDE DERIVATIVES AS THERAPEUTIC AGENTS | Transtech Pharma, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| US-20020193432-A1 | Carboxamide derivatives as therapeutic agents | VTVX HOLDINGS I LLC | 2002-12-19 | — | — | US | disclosed |
| WO-2002070473-A2 | CARBOXAMIDE DERIVATIVES AS THERAPEUTIC AGENTS | TRANSTECH PHARMA, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286197-A1 | Carboxamide Derivatives As Therapeutic Agents | AGER, S100B, S100A4 | MAPT 655/4885KDM4E 2929/4885ALDH1A1 2785/4885 |
| US-20020193432-A1 | Carboxamide derivatives as therapeutic agents | AGER, S100B, S100A4 | MAPT 624/4885KDM4E 2900/4885ALDH1A1 2802/4885 |
| US-20080119512-A1 | Carboxamide Derivatives as Therapeutic Agents | AGER, S100B, S100A4 | MAPT 655/4885KDM4E 2929/4885ALDH1A1 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.