Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | NAMPT | P43490 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651774 | 0.88 | POLB (0.69) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL10693788 | 0.84 | NAMPT (0.60) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL1439066 | 0.83 | NAMPT (0.67) | NAMPTSMN1; SMN2KMT2AKDM4EHTT | |
| SCHEMBL12310125 | 0.83 | RAB9A (1.00) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL3662909 | 0.83 | SMN1; SMN2 (0.71) | NPC1RAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL822378 | 0.83 | RAB9A (1.00) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL27181403 | 0.83 | RAB9A (1.00) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL15214321 | 0.83 | RAB9A (1.00) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL14580374 | 0.83 | RAB9A (1.00) | NPC1RAB9ANAMPTSMN1; SMN2MAPT | |
| SCHEMBL10685426 | 0.83 | NR1H4 (0.73) | NPC1RAB9ASMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112472699-A | Combination methods for improving the therapeutic benefit of bisantrene and derivatives | 种族肿瘤学公司 | 2021-03-12 | — | — | CN | disclosed |