SCHEMBL28916331

SCHEMBL28916331

O=C1NC(=S)NC1c1ccc(O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GUSB P08236 1/20 0.50
ALDH1A1 P00352 7/20 0.47
TDP1 Q9NUW8 1/20 0.44
KMT2A Q03164 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
GAA P10253 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.40
ALOX12 P18054 1/20 0.40
MC4R P32245 1/20 0.40
OPRM1 P35372 1/20 0.40
OPRD1 P41143 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
DHFR P00374 1/20 0.39
NAT1 P18440 1/20 0.39
ESR2 Q92731 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1421442 0.81 TDP1 (0.68) ALDH1A1TDP1KMT2ACYP2C9CYP2C19
SCHEMBL1014744 0.81 TDP1 (0.67) ALDH1A1TDP1KMT2AGAAMAPT
SCHEMBL28470699 0.81 TDP1 (0.67) ALDH1A1TDP1KMT2AGAAMAPT
SCHEMBL62941 0.81 ALDH1A1 (0.58) GUSBALDH1A1TDP1KMT2AGAA
SCHEMBL12157332 0.80 ESR2 (0.47) ALDH1A1TDP1KMT2ACYP3A4GAA
SCHEMBL9701173 0.80 DHFR (0.62) GUSBALDH1A1GAAMAPTHTT
Nitrous Acid SCHEMBL1979274 0.77 ALDH1A1 (0.50) GUSBALDH1A1TDP1KMT2AMAPT
SCHEMBL14164074 0.74 DHFR (0.71) GUSBALDH1A1MAPTDHFRCA12
Alanine SCHEMBL891875 0.72 ALDH1A1 (0.48) GUSBALDH1A1TDP1KMT2AGAA
SCHEMBL14164075 0.70 ALDH1A1 (0.71) GUSBALDH1A1KMT2AGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115504918-A Gallic acid derivative containing thiosemicarbazide phenol acyl group, and synthesis method and application thereof 江苏海洋大学 2022-12-23 CN disclosed