Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24625 | 0.85 | TDP1 (0.58) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL2888762 | 0.84 | TDP1 (0.54) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL24485691 | 0.75 | TDP1 (0.51) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL7434 | 0.74 | TDP1 (0.65) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL229087 | 0.73 | TDP1 (0.68) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL3341020 | 0.72 | TDP1 (0.67) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL1041731 | 0.71 | TDP1 (0.71) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL21596987 | 0.71 | TDP1 (0.71) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL19460948 | 0.71 | TDP1 (0.71) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL18604607 | 0.71 | TDP1 (0.71) | TDP1MEN1GAAKMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9526711-B2 | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160279086-A1 | BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR | AUSPEX PHARMACEUTICALS INC (US) | 2016-09-29 | — | — | US | disclosed |
| US-9394239-B2 | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20140286931-A1 | BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR | AUSPEX PHARMACEUTICALS, INC. | 2014-09-25 | — | — | US | disclosed |
| US-8778998-B2 | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor | AUSPEX PHARMACEUTICALS, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20100286275-A1 | BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286275-A1 | BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR | ADRB3, ADRB1, ADRA2C | TDP1 4614/4885MEN1 4307/4885GAA 2625/4885 |
| US-20160279086-A1 | BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR | ADRB3, ADRB1, ADRA2C | TDP1 4614/4885MEN1 4307/4885GAA 2625/4885 |
| US-20140286931-A1 | BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR | ADRB3, ADRB1, ADRA2C | TDP1 4614/4885MEN1 4307/4885GAA 2625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.