Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.49 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29929924 | 0.88 | MAP3K7 (0.47) | MAP4K3MAP3K7TAB1 | |
| SCHEMBL28927885 | 0.87 | MAP4K3 (0.43) | MAP4K3MAP3K7TAB1ACVRL1ACVR1 | |
| SCHEMBL28636439 | 0.85 | MAP3K7 (0.51) | MAP4K3MAP3K7TAB1 | |
| SCHEMBL28962175 | 0.84 | KDM1A (0.45) | MAP4K3ACVRL1ACVR1METALK | |
| SCHEMBL28927859 | 0.81 | MAP3K7 (0.45) | MAP4K3MAP3K7TAB1 | |
| SCHEMBL28638645 | 0.79 | MAP4K3 (0.39) | MAP4K3CHRNB2CHRNA4 | |
| SCHEMBL28927866 | 0.75 | MAP4K1 (0.46) | ACVRL1ACVR1BMPR1A | |
| SCHEMBL28927864 | 0.75 | PIM1 (0.43) | — | |
| SCHEMBL28633555 | 0.73 | MAP4K1 (0.42) | — | |
| SCHEMBL29929741 | 0.73 | MAP4K1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115244050-B | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115244050-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-113336747-A | Novel HPK1 inhibitor and preparation method and application thereof | 轶诺(浙江)药业有限公司 | 2021-09-03 | — | — | CN | disclosed |