Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096443 | 0.77 | LMNA (0.46) | LMNAHTTSTAT3SMN1; SMN2L3MBTL1 | |
| SCHEMBL25101188 | 0.68 | LMNA (0.68) | LMNAHTTSTAT3SMN1; SMN2L3MBTL1 | |
| SCHEMBL9284380 | 0.68 | PDGFRB (0.51) | LMNAHTTSTAT3SMN1; SMN2MAPK1 | |
| SCHEMBL865299 | 0.66 | L3MBTL1 (0.50) | LMNAHTTSTAT3SMN1; SMN2L3MBTL1 | |
| SCHEMBL24556374 | 0.66 | L3MBTL1 (0.49) | LMNAHTTSTAT3SMN1; SMN2L3MBTL1 | |
| SCHEMBL5370441 | 0.65 | PKM (0.44) | LMNAL3MBTL1NPC1RAB9AHCAR2 | |
| SCHEMBL2465344 | 0.65 | LMNA (0.51) | LMNAHTTSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL6500546 | 0.64 | MAPK14 (0.49) | LMNAHTTSTAT3SMN1; SMN2L3MBTL1 | |
| SCHEMBL1478411 | 0.63 | LMNA (0.47) | LMNAHTTSTAT3SMN1; SMN2L3MBTL1 | |
| SCHEMBL18851681 | 0.63 | LMNA (0.63) | LMNAL3MBTL1MAPK1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605479-B | Pyridopyrimidine derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-115605479-A | Pyridoneopyrimidine derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |