Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843607 | 0.85 | ESR1 (0.47) | DGAT1LIMK2ESR1PDE6DBRD4 | |
| SCHEMBL2153326 | 0.84 | DGAT1 (0.40) | DGAT1LIMK2MAPTESR1PDE6D | |
| SCHEMBL1441203 | 0.84 | DGAT1 (0.46) | DGAT1ESR1PDE6DBRD4 | |
| SCHEMBL9638271 | 0.83 | DGAT1 (0.41) | DGAT1 | |
| SCHEMBL18865495 | 0.82 | DGAT1 (0.39) | DGAT1LIMK2ESR1PDE6DBRD4 | |
| SCHEMBL7836831 | 0.80 | MAPT (0.41) | DGAT1MAPTESR1BRD4 | |
| SCHEMBL22409097 | 0.79 | DGAT1 (0.36) | DGAT1MAPT | |
| SCHEMBL1440980 | 0.77 | LPL (0.40) | DGAT1 | |
| SCHEMBL7524797 | 0.77 | DGAT1 (0.40) | DGAT1PDE6DBRD4 | |
| SCHEMBL14812742 | 0.76 | DGAT1 (0.42) | DGAT1MAPTESR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114702495-A | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-108473495-B | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2022-04-12 | — | — | CN | disclosed |