Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.58 |
| ▸ | BCKDK | O14874 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1443637 | 0.88 | GPR35 (0.53) | GPR35BCKDKTBXAS1RXFP1PKM | |
| SCHEMBL6963675 | 0.87 | CMA1 (0.46) | GPR35BCKDKTBXAS1RXFP1NPSR1 | |
| SCHEMBL2895162 | 0.87 | BCKDK (0.67) | GPR35BCKDKTBXAS1RXFP1PKM | |
| SCHEMBL10007005 | 0.84 | GPR35 (0.49) | GPR35BCKDKTBXAS1RXFP1PKM | |
| SCHEMBL2895952 | 0.83 | GPR35 (0.62) | GPR35BCKDKTBXAS1RXFP1PKM | |
| SCHEMBL4342850 | 0.83 | CMA1 (0.41) | GPR35BCKDKTBXAS1RXFP1PRNP | |
| SCHEMBL31126911 | 0.83 | TRPM8 (0.42) | GPR35BCKDKTBXAS1RXFP1PRNP | |
| SCHEMBL9757077 | 0.81 | GPR35 (0.65) | GPR35BCKDKTBXAS1RXFP1PKM | |
| SCHEMBL1066852 | 0.80 | GPR35 (0.58) | GPR35BCKDKTBXAS1RXFP1PKM | |
| SCHEMBL2896475 | 0.80 | GPR35 (0.58) | GPR35TBXAS1RXFP1PKMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732477-B2 | N-(1-azabicyclo[2.2.2]oct-3-yl)-heteroaryl carboxamides; alpha 7-nicotinic acetylcholine receptors (nAChR) agonists; improving perception, concentration, learning and memory; neuropathic pain; acute and chronic pain | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-08 | — | — | US | disclosed |