Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 2/20 | 0.32 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM3B | Q7LBC6 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199838 | 0.78 | KDM4E (0.45) | HCAR2ALDH1A1RAB9ACYP3A4TSHR | |
| SCHEMBL5199832 | 0.78 | KDM4E (0.45) | HCAR2ALDH1A1RAB9ACYP3A4TSHR | |
| Acetic Acid SCHEMBL21996138 | 0.71 | BRS3 (0.43) | HCAR2LMNAALDH1A1CYP3A4TSHR | |
| SCHEMBL14037700 | 0.71 | — | — | |
| SCHEMBL4506135 | 0.71 | PIN1 (0.46) | HCAR2KDM4EKDM6BKDM4AKDM3B | |
| Fumaric Acid SCHEMBL28937804 | 0.69 | HCAR2 (0.36) | HCAR2LMNAALDH1A1CYP3A4TSHR | |
| SCHEMBL19323027 | 0.68 | SMN1; SMN2 (0.38) | LMNARAB9AKDM4EPOLBKMT2A | |
| SCHEMBL16177862 | 0.65 | — | — | |
| Maleic Acid SCHEMBL27430990 | 0.64 | KDM4E (0.44) | HCAR2LMNAALDH1A1RAB9ACYP3A4 | |
| SCHEMBL22871224 | 0.63 | TSHR (0.42) | ALDH1A1TSHRKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114207043-B | Composition for producing siliceous film having low dielectric constant and method for producing cured film and electronic device using the same | 默克专利有限公司 | 2023-09-15 | — | — | CN | claimed |
| CN-114207043-A | Composition for producing low dielectric constant siliceous film and method for producing cured film and electronic device using the same | 默克专利有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-114207043-A | Composition for producing low dielectric constant siliceous film and method for producing cured film and electronic device using the same | 默克专利有限公司 | 2022-03-18 | — | — | CN | disclosed |