Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 11/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16827279 | 0.86 | POLB (0.64) | POLBKDM4EHTTAOC3PTPN11 | |
| SCHEMBL29224913 | 0.85 | ALDH1A1 (0.40) | POLBKDM4EAOC3PTPN11ALDH1A1 | |
| SCHEMBL29177386 | 0.84 | POLB (0.44) | POLBKDM4EAOC3PTPN11ALDH1A1 | |
| SCHEMBL28940962 | 0.81 | ALDH1A1 (0.55) | POLBKDM4EHTTAOC3ALDH1A1 | |
| SCHEMBL28941031 | 0.79 | SMN1; SMN2 (0.44) | POLBKDM4EALDH1A1 | |
| SCHEMBL3126575 | 0.79 | POLB (0.73) | POLBKDM4EHTTAOC3PTPN11 | |
| SCHEMBL3914229 | 0.76 | AKR1C3 (0.51) | KDM4EHTTALDH1A1 | |
| SCHEMBL24921466 | 0.75 | POLB (0.53) | POLBKDM4EPIK3CAMTORALDH1A1 | |
| SCHEMBL28053591 | 0.75 | POLB (0.77) | POLBKDM4EHTTPTPN11PIK3R1 | |
| SCHEMBL28294314 | 0.75 | HRH3 (0.57) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | claimed |
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |