Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23052072 | 0.81 | CYP1A2 (0.50) | KMT2AMEN1P2RX7MAPK14ALDH1A1 | |
| SCHEMBL4034946 | 0.81 | ALDH1A1 (0.51) | KMT2AMEN1P2RX7MAPK14HTT | |
| SCHEMBL23134945 | 0.80 | HPGD (0.57) | KMT2AMEN1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL32665423 | 0.80 | HPGD (0.43) | KMT2AMEN1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL28822084 | 0.79 | LMNA (0.53) | KMT2AP2RX7HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8696462 | 0.79 | KMT2A (0.42) | KMT2AMEN1P2RX7MAPK14HTT | |
| SCHEMBL15295190 | 0.79 | CYP3A4 (0.51) | P2RX7ALDH1A1HPGD | |
| SCHEMBL3557822 | 0.79 | CYP1A2 (0.48) | KMT2AMEN1P2RX7MAPK14ALDH1A1 | |
| SCHEMBL22803047 | 0.77 | MCL1 (0.58) | KMT2AMEN1P2RX7MAPK14HTT | |
| SCHEMBL2997305 | 0.77 | P2RX7 (0.55) | KMT2AMEN1P2RX7HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-114787145-A | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 奥里戈生物制药有限公司 | 2022-07-22 | — | — | CN | disclosed |