Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167361 | 0.80 | CYP1A2 (0.60) | P2RX7SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL6360985 | 0.79 | P2RX7 (0.60) | P2RX7SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL28822084 | 0.79 | LMNA (0.53) | P2RX7SMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL6357149 | 0.78 | ATM (0.59) | P2RX7SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL19425617 | 0.77 | P2RX7 (0.54) | P2RX7SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL28948874 | 0.77 | KMT2A (0.44) | P2RX7SMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL6357738 | 0.76 | ATM (0.56) | P2RX7HTTATMALDH1A1KMT2A | |
| SCHEMBL2472420 | 0.76 | P2RX7 (0.62) | P2RX7SMN1; SMN2HTTATMALDH1A1 | |
| SCHEMBL3460926 | 0.76 | LMNA (0.64) | P2RX7SMN1; SMN2HTTATMMAPT | |
| SCHEMBL6361747 | 0.75 | LMNA (0.56) | P2RX7SMN1; SMN2ATMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| EP-2091538-B1 | 4-BENZYL-1(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184770-A1 | COMPOUNDS | CMA1, TSLP, IL5 | P2RX7 488/4885SMN1; SMN2 4658/4885HTT 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.