Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873970 | 0.86 | ALDH1A1 (0.46) | TSHRCES2CES1ALDH1A1AKR1B1 | |
| SCHEMBL10471783 | 0.84 | CES2 (0.52) | TSHRCES2TDP1ALDH1A1AKR1B1 | |
| SCHEMBL15277221 | 0.80 | TSHR (0.42) | HDAC1HDAC2HDAC3HDAC8FFAR3 | |
| SCHEMBL901650 | 0.79 | — | — | |
| SCHEMBL2418243 | 0.76 | — | — | |
| Succinic Acid SCHEMBL11510947 | 0.75 | HDAC1 (0.50) | HDAC1HDAC2HDAC3HDAC8FFAR3 | |
| SCHEMBL1920127 | 0.75 | ALDH1A1 (0.39) | HDAC1HDAC2HDAC3HDAC8FFAR3 | |
| SCHEMBL2720085 | 0.74 | — | — | |
| SCHEMBL4940589 | 0.74 | HDAC1 (0.48) | HDAC1HDAC2HDAC3HDAC8FFAR3 | |
| SCHEMBL11458916 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115466254-A | Inhibitor and preparation method thereof | 安庆研至医药科技有限公司 | 2022-12-13 | — | — | CN | claimed |
| CN-112662639-B | Short-chain alcohol dehydrogenase and application thereof | 江南大学 | 2022-05-24 | — | — | CN | claimed |
| CN-111518104-B | 1,2, 4-triazolo [1,5-a ] pyrimidine compound containing thiourea pyrimidine and preparation method and application thereof | 河北农业大学 | 2022-04-15 | — | — | CN | claimed |
| CN-109456192-B | Synthetic method of oxiracetam intermediate 4-ethyl chloroacetoacetate | 深圳市第二人民医院 | 2022-04-01 | — | — | CN | claimed |
| CN-109704971-B | Preparation method of ethyl 4-chloroacetoacetate | 江苏恒安化工有限公司 | 2022-04-01 | — | — | CN | claimed |
| US-20210198129-A1 | METHODS, PRODUCTS & USES RELATING TO SCAVENGING OF ACIDIC SULFIDE SPECIES | INNOSPEC LIMITED (GB) | 2021-07-01 | — | — | US | claimed |
| US-20210197116-A1 | METHOD OF SCAVENGING ACID SULFIDE SPECIES | INNOSPEC LIMITED (GB) | 2021-07-01 | — | — | US | claimed |
| EP-3840858-A1 | METHOD OF SCAVENGING ACID SULFIDE SPECIES | Innospec Limited (GB) | 2021-06-30 | — | — | EP | claimed |
| EP-3840857-A1 | METHODS, PRODUCTS & USES RELATING TO SCAVENGING OF ACIDIC SULFIDE SPECIES | Innospec Limited (GB) | 2021-06-30 | — | — | EP | claimed |
| CN-109232314-B | Synthesis method of polysubstituted 2-cyclopentenyl ethyl acetate compound | 河南理工大学 | 2021-04-06 | — | — | CN | claimed |
| US-20150353541-A1 | Novel intermediate and polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof | THIRUMALAI RAJAN SRINIVASAN (US) | 2015-12-10 | — | — | US | claimed |
| WO-2014108919-A2 | NOVEL INTERMEDIATE AND POLYMORPHS OF 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-c] PYRIDINE-3-CARBOXAMIDE AND PROCESS THEREOF | MSN LABORATORIES LIMITED (IN) | 2014-07-17 | — | — | WO | claimed |
| WO-2014057461-A1 | PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM G OF FEBUXOSTAT | RANBAXY LABORATORIES LIMITED (IN) | 2014-04-17 | — | — | WO | claimed |
| EP-2386548-A2 | Preparation of thionamides | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | claimed |
| US-7541475-B2 | Substituted thiazoles | ABBOTT LABORATORIES (US) | 2009-06-02 | — | — | US | claimed |
| JP-2007500724-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651624-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES | Abbott Laboratories (US) | 2006-05-03 | — | — | EP | claimed |
| US-20050075503-A1 | Substituted thiazoles | ABBVIE INC. | 2005-04-07 | — | — | US | claimed |
| WO-2005012273-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES | ABBOTT LABORATORIES (US) | 2005-02-10 | — | — | WO | claimed |
| US-20050027128-A1 | Substituted thiazoles | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050027128-A1 | Substituted thiazoles | XDH, TH, TPI1 | HDAC1 743/4885HDAC2 938/4885HDAC3 1189/4885 |
| US-20050075503-A1 | Substituted thiazoles | XDH, TH, TPI1 | HDAC1 743/4885HDAC2 938/4885HDAC3 1189/4885 |
| US-20150353541-A1 | Novel intermediate and polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof | CYP3A4, CYP4B1, CYP1A1 | HDAC1 382/4885HDAC2 460/4885HDAC3 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.