Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | KAT7 | O95251 | 3/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.33 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.32 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825445 | 0.84 | GRIN2B (0.51) | GRIN2BGRIN1KCNH2KLKB1 | |
| SCHEMBL28825565 | 0.84 | GRIN2B (0.43) | GRIN2BGRIN1GAAMAPTBRD4 | |
| SCHEMBL28825483 | 0.77 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL28825473 | 0.74 | GAA (0.46) | GRIN2BGRIN1KCNH2GAAMAPT | |
| SCHEMBL28028438 | 0.71 | MAPT (0.35) | GRIN2BGRIN1GAAMAPTBRD4 | |
| SCHEMBL30046359 | 0.69 | HTT (0.47) | GAAMAPTBRD4KAT7KAT6A | |
| SCHEMBL31735733 | 0.69 | AGBL2 (0.48) | GRIN2BGRM5 | |
| SCHEMBL28825573 | 0.68 | GRIN2B (0.41) | GRIN2BGRIN1GAAMAPTBRD4 | |
| SCHEMBL31432587 | 0.66 | PDE4A (0.40) | GRIN2BGAAMAPTBRD4KAT7 | |
| SCHEMBL31735547 | 0.65 | GRM5 (0.39) | GRM5MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |