Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Favipiravir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Favipiravir SCHEMBL587913 | 0.82 | LCK (0.34) | — | |
| Favipiravir SCHEMBL30725561 | 0.81 | LCK (0.33) | — | |
| Favipiravir SCHEMBL28964779 | 0.74 | LMNA (0.32) | — | |
| SCHEMBL28456157 | 0.74 | CTSK (0.39) | OPRK1 | |
| SCHEMBL28685100 | 0.69 | PDGFRB (0.44) | — | |
| SCHEMBL5269681 | 0.69 | PLAU (0.33) | — | |
| SCHEMBL31259490 | 0.69 | PLAU (0.33) | — | |
| SCHEMBL28707329 | 0.68 | PDGFRB (0.43) | — | |
| SCHEMBL6376447 | 0.67 | KMT2A (0.32) | — | |
| SCHEMBL28398570 | 0.67 | KDM4E (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677602-A | Refining method of Favipiravir | 浙江华海药业股份有限公司 | 2023-02-03 | — | — | CN | disclosed |