Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imetit SCHEMBL7974417 | 0.98 | HRH4 (0.50) | HRH4NPSR1HRH3CYP2D6ADRA2A | |
| Imetit SCHEMBL31157603 | 0.98 | HRH4 (0.50) | HRH4NPSR1HRH3CYP2D6ADRA2A | |
| SCHEMBL27550976 | 0.90 | HRH4 (0.51) | HRH4NPSR1HRH3CYP2D6ADRA2A | |
| SCHEMBL31157604 | 0.79 | — | — | |
| Histamine SCHEMBL27489895 | 0.77 | HRH4 (0.34) | HRH4HRH3TDP1TSHRCYP2C19 | |
| SCHEMBL2893700 | 0.74 | SPHK2 (0.31) | LMNA | |
| Histamine SCHEMBL4234179 | 0.74 | HRH4 (0.39) | HRH4HRH3TDP1LMNATSHR | |
| Histamine SCHEMBL28543874 | 0.74 | HRH4 (0.39) | HRH4HRH3TDP1LMNATSHR | |
| Histamine SCHEMBL1668636 | 0.73 | HRH4 (0.42) | HRH4HRH3TDP1LMNATSHR | |
| Histamine SCHEMBL5447892 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240269123-A1 | MUSCLE REGENERATION PROMOTER | SATO PHARMACEUTICAL CO., LTD. (JP) | 2024-08-15 | — | — | US | claimed |
| US-20100137391-A1 | Histamine H3 Agonist for use as Therapeutic Agent for a Lipid/Glucose Metabolic Disorder | MSD K.K. (JP) | 2010-06-03 | — | — | US | claimed |
| EP-1938838-A1 | HISTAMINE H3 AGONIST FOR USE AS THERAPEUTIC AGENT FOR LIPID/GLUCOSE METABOLIC DISORDER | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-07-02 | — | — | EP | claimed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | claimed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | claimed |
| US-20240269123-A1 | MUSCLE REGENERATION PROMOTER | SATO PHARMACEUTICAL CO., LTD. (JP) | 2024-08-15 | — | — | US | disclosed |
| WO-2022255250-A1 | MUSCLE REGENERATION PROMOTER | 佐藤製薬株式会社 | 2022-12-08 | — | — | WO | disclosed |
| US-9034798-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | CAPROTEC BIOANALYTICS GMBH (DE) | 2015-05-19 | — | — | US | disclosed |
| US-8569481-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | KOESTER HUBERT | 2011-05-19 | — | — | US | disclosed |
| US-20100298168-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | HK PHARMACEUTICALS, INC. | 2010-11-25 | — | — | US | disclosed |
| US-20100248264-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | HK PHARMACEUTICALS, INC. | 2010-09-30 | — | — | US | disclosed |
| US-20100137391-A1 | Histamine H3 Agonist for use as Therapeutic Agent for a Lipid/Glucose Metabolic Disorder | MSD K.K. (JP) | 2010-06-03 | — | — | US | disclosed |
| EP-1938838-A1 | HISTAMINE H3 AGONIST FOR USE AS THERAPEUTIC AGENT FOR LIPID/GLUCOSE METABOLIC DISORDER | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-07-02 | — | — | EP | disclosed |
| US-5837718-A | ANTIHISTAMINES | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1998-11-17 | — | — | US | disclosed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PTMS, QPCTL, SRMS | HRH4 4303/4885NPSR1 2055/4885HRH3 4238/4885 |
| US-20100137391-A1 | Histamine H3 Agonist for use as Therapeutic Agent for a Lipid/Glucose Metabolic Disorder | GPR119, HRH3, HRH4 | HRH4 3/4885NPSR1 598/4885HRH3 2/4885 |
| US-20240269123-A1 | MUSCLE REGENERATION PROMOTER | MUSK, HRH3, HGF | HRH4 7/4885NPSR1 1464/4885HRH3 2/4885 |
| US-20100298168-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | CHLSN, PTMS, SRMS | HRH4 4411/4885NPSR1 3486/4885HRH3 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.