Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889379 | 0.80 | GPR35 (0.44) | GPR35RXFP1PRNPPKMNPSR1 | |
| SCHEMBL2897560 | 0.76 | MCL1 (0.52) | KMT2AGPR35RXFP1PRNPDHODH | |
| SCHEMBL1851331 | 0.76 | GPR35 (0.60) | GPR35RXFP1PRNPPKMNPSR1 | |
| SCHEMBL17434168 | 0.75 | PDE10A (0.55) | GPR35RXFP1PRNPPDE10A | |
| SCHEMBL12095403 | 0.74 | HDAC3 (0.36) | MEN1POLBKMT2ATAS2R14HDAC6 | |
| SCHEMBL2897567 | 0.74 | PFKFB4 (0.53) | MEN1POLBKMT2AGPR35ALDH1A1 | |
| SCHEMBL25871160 | 0.72 | HDAC3 (0.43) | MEN1POLBKMT2AHDAC6HDAC3 | |
| SCHEMBL15700017 | 0.72 | TBXAS1 (0.44) | MEN1KMT2ATAS2R14HDAC6HDAC3 | |
| SCHEMBL2956013 | 0.72 | RBP4 (0.43) | POLBALDH1A1SLC9A1 | |
| SCHEMBL17433927 | 0.72 | PDE10A (0.53) | GPR35RXFP1PRNPPKMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732477-B2 | N-(1-azabicyclo[2.2.2]oct-3-yl)-heteroaryl carboxamides; alpha 7-nicotinic acetylcholine receptors (nAChR) agonists; improving perception, concentration, learning and memory; neuropathic pain; acute and chronic pain | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-08 | — | — | US | disclosed |