Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28964198 | 1.00 | TSHR (0.52) | TSHRL3MBTL1GFERMEN1KMT2A | |
| SCHEMBL28946571 | 0.85 | TSHR (0.54) | TSHRL3MBTL1GFERMEN1KMT2A | |
| SCHEMBL28946573 | 0.85 | TSHR (0.54) | TSHRL3MBTL1GFERMEN1KMT2A | |
| SCHEMBL6172743 | 0.81 | L3MBTL1 (0.51) | TSHRL3MBTL1GFERKMT2AALDH1A1 | |
| SCHEMBL31427469 | 0.79 | SIGMAR1 (0.45) | NPSR1TMEM97SIGMAR1PREPACE2 | |
| SCHEMBL13230394 | 0.79 | KDM4E (0.71) | TSHRL3MBTL1GFERMEN1KMT2A | |
| SCHEMBL30511007 | 0.78 | OPRD1 (0.49) | TSHRL3MBTL1GFERKMT2ANPSR1 | |
| SCHEMBL27978282 | 0.78 | FKBP1A (0.52) | TSHRL3MBTL1KMT2ANPSR1KDM4E | |
| SCHEMBL3070354 | 0.78 | PDE4B (0.49) | TSHRL3MBTL1GFERKMT2AALDH1A1 | |
| SCHEMBL3070355 | 0.78 | PDE4B (0.49) | TSHRL3MBTL1GFERKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115490708-B | Sulfonamide macrocyclic derivative, preparation method and application thereof | 苏州亚盛药业有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-115490708-A | Sulfonamide macrocyclic derivatives, and preparation method and application thereof | 苏州亚盛药业有限公司 | 2022-12-20 | — | — | CN | disclosed |