Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30174243 | 0.80 | CHEK1 (0.39) | KDM4ECHEK1CHEK2 | |
| SCHEMBL30174299 | 0.80 | KDM4E (0.36) | KDM4ESYKALDH1A1HPGD | |
| SCHEMBL30174265 | 0.78 | CYP2A6 (0.43) | ALDH1A1MAPTHPGD | |
| SCHEMBL30174264 | 0.78 | NNMT (0.39) | KDM4ESYKGRIN1GRIN2B | |
| SCHEMBL30174203 | 0.77 | ERCC1 (0.46) | KDM4EERCC1FEN1ERCC4GAA | |
| SCHEMBL4341035 | 0.76 | KDM4E (0.44) | NEK2KDM4ECHEK1CHEK2ERCC1 | |
| SCHEMBL30174194 | 0.76 | CHEK2 (0.45) | KDM4ECHEK1CHEK2BTKGRIN2D | |
| SCHEMBL30174294 | 0.76 | CHEK2 (0.40) | CHEK2SYKALDH1A1MAPT | |
| SCHEMBL30174200 | 0.76 | KDM4E (0.51) | NEK2KDM4ECHEK1CHEK2ERCC1 | |
| SCHEMBL4314650 | 0.74 | KDM4E (0.43) | NEK2KDM4ECHEK1CHEK2ERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605478-A | Compounds and methods of use | 埃克塞里艾克西斯公司（US） | 2023-01-13 | — | — | CN | claimed |
| CN-115605478-A | Compounds and methods of use | 埃克塞里艾克西斯公司（US） | 2023-01-13 | — | — | CN | disclosed |