Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | FOS | P01100 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288852 | 0.80 | KDM4E (0.59) | JAK2JAK3DHODHNPC1RAB9A | |
| SCHEMBL299236 | 0.77 | MAPT (0.42) | DHODHNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL290424 | 0.76 | CDC7 (0.52) | JAK2JAK3TNIKFOSJUN | |
| SCHEMBL289667 | 0.75 | JAK2 (0.49) | JAK2JAK3TNIKFOSJUN | |
| SCHEMBL6500653 | 0.75 | ALDH1A1 (0.55) | DHODHNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL289682 | 0.74 | ALDH1A1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL289614 | 0.74 | KDM4E (0.64) | JAK2JAK3DHODHNPC1RAB9A | |
| SCHEMBL3399928 | 0.73 | CDC25B (0.49) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL289540 | 0.73 | KDM4E (0.54) | JAK2JAK3TNIKDHODHNPC1 | |
| SCHEMBL290062 | 0.73 | JAK2 (0.46) | JAK2JAK3FOSJUNNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |