Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289682 | 0.78 | ALDH1A1 (0.61) | MAPTNPSR1NPC1RAB9APOLB | |
| SCHEMBL289663 | 0.77 | JAK2 (0.47) | MAPTNPSR1NPC1RAB9APTGS2 | |
| SCHEMBL6500653 | 0.76 | ALDH1A1 (0.55) | MAPTNPSR1NPC1RAB9ACYP1A2 | |
| SCHEMBL289847 | 0.76 | KDM4E (0.64) | MAPTNPSR1NPC1RAB9AKDM4E | |
| SCHEMBL14380356 | 0.75 | PTGS2 (0.51) | MAPTRAB9APOLBPTGS2KDM4E | |
| SCHEMBL9586131 | 0.75 | NPC1 (0.41) | MAPTNPSR1NPC1RAB9APOLB | |
| SCHEMBL289991 | 0.75 | ALDH1A1 (0.43) | MAPTNPSR1NPC1RAB9APOLB | |
| SCHEMBL14380747 | 0.74 | PTGS2 (0.65) | MAPTNPSR1NPC1RAB9APKM | |
| SCHEMBL14485340 | 0.73 | GAA (0.58) | MAPTNPSR1NPC1RAB9APOLB | |
| SCHEMBL14485326 | 0.73 | HTT (0.47) | MAPTPOLBPTGS2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |