Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500653 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL299236 | 0.78 | MAPT (0.42) | ALDH1A1KDM4EKMT2AHPGDMAPT | |
| SCHEMBL5759200 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL5761572 | 0.77 | ALDH1A1 (0.55) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL290132 | 0.76 | KDM4E (1.00) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL14380356 | 0.75 | PTGS2 (0.51) | KDM4EKMT2AGAAMAPTRAB9A | |
| SCHEMBL3399928 | 0.75 | CDC25B (0.49) | ALDH1A1KDM4EKMT2AHPGDMAPT | |
| SCHEMBL23079540 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL290007 | 0.74 | KDM4E (0.76) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL289663 | 0.74 | JAK2 (0.47) | ALDH1A1KDM4EKMT2AHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |