Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | FABP7 | O15540 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 8/20 | 0.35 |
| ▸ | MMP3 | P08254 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29113484 | 0.87 | BRD4 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6200513 | 0.85 | ALDH1A1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7909110 | 0.82 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28445305 | 0.81 | PNMT (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27689519 | 0.81 | PNMT (0.40) | HSD17B3 | |
| SCHEMBL30685660 | 0.80 | IDO1 (0.54) | FABP7FABP5IDO1CA1CA2 | |
| SCHEMBL28654763 | 0.78 | PNMT (0.40) | — | |
| SCHEMBL28448081 | 0.78 | PNMT (0.43) | KDM4EMAPTHSD17B10ALDH1A1HPGD | |
| SCHEMBL27468308 | 0.77 | BRD4 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28675469 | 0.76 | PNMT (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697995-A | Aminopyrimidinamides | 豪夫迈·罗氏有限公司 | 2023-02-03 | — | — | CN | disclosed |