SCHEMBL28974764

SCHEMBL28974764

ON=Cc1nnn(-c2ccc(C(F)F)cc2)c1COc1ccc(Cl)nn1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25044714 1.00 GABRG2 (0.30) GABRG2GABRB3GABRA5KCNH2
SCHEMBL30283014 1.00 GABRG2 (0.30) GABRG2GABRB3GABRA5KCNH2
SCHEMBL30237342 0.87 GABRG2 (0.32) GABRG2GABRB3GABRA5KCNH2
SCHEMBL25045504 0.87 GABRG2 (0.32) GABRG2GABRB3GABRA5KCNH2
SCHEMBL25045285 0.84 RXRA (0.33) GABRG2GABRB3GABRA5KCNH2
SCHEMBL25045392 0.83 RXRA (0.33) GABRG2GABRB3GABRA5KCNH2
SCHEMBL30283165 0.83 RXRA (0.33) GABRG2GABRB3GABRA5KCNH2
SCHEMBL27242697 0.81 ALDH1A1 (0.40) GABRG2GABRB3GABRA5KCNH2
SCHEMBL21623964 0.81 GABRA5 (0.43) GABRG2GABRB3GABRA5KCNH2
SCHEMBL30282856 0.81 GABRA5 (0.43) GABRG2GABRB3GABRA5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115703765-A Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof 上海赛默罗生物科技有限公司 2023-02-17 CN disclosed