SCHEMBL28974765

SCHEMBL28974765

C[Si](C)(C)c1nnn(-c2ccc(C(F)F)cc2)c1CO

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
NOTUM Q6P988 1/20 0.35
CYP1A2 P05177 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25045280 0.84 ALDH1A1 (0.44) ALDH1A1NOTUMCYP1A2L3MBTL1
SCHEMBL21623953 0.82 ALDH1A1 (0.43) ALDH1A1NOTUMCYP1A2L3MBTL1
SCHEMBL25044736 0.77 CYP1A2 (0.42) ALDH1A1NOTUMCYP1A2L3MBTL1
SCHEMBL25045351 0.75 ALDH1A1 (0.39) ALDH1A1NOTUMCYP1A2
SCHEMBL25044718 0.75 L3MBTL1 (0.54) ALDH1A1L3MBTL1
SCHEMBL30283010 0.75 GRIN1 (0.33)
SCHEMBL25045189 0.74 ALDH1A1 (0.42) ALDH1A1NOTUMCYP1A2
SCHEMBL25045416 0.73 ALDH1A1 (0.47) ALDH1A1NOTUMCYP1A2
SCHEMBL29036214 0.71 NPBWR1 (0.34) ALDH1A1NOTUM
SCHEMBL25043902 0.67 HSD11B1 (0.38) ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115703765-B Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof 上海赛默罗生物科技有限公司 2025-02-28 CN disclosed
CN-115703765-A Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof 上海赛默罗生物科技有限公司 2023-02-17 CN disclosed