Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 3/20 | 0.39 |
| ▸ | FURIN | P09958 | 2/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28974940 | 1.00 | KLK7 (0.39) | KLK7FURINSIRT1CASP3HTT | |
| SCHEMBL28425032 | 0.92 | KLK7 (0.37) | KLK7FURINSIRT1CASP3HTT | |
| SCHEMBL28425028 | 0.92 | KLK7 (0.37) | KLK7FURINSIRT1CASP3HTT | |
| SCHEMBL29211699 | 0.92 | SIRT1 (0.38) | KLK7FURINSIRT1CASP3HTT | |
| SCHEMBL29211700 | 0.92 | SIRT1 (0.38) | KLK7FURINSIRT1CASP3HTT | |
| SCHEMBL28681266 | 0.91 | FURIN (0.37) | KLK7FURINSIRT1CASP3HTT | |
| SCHEMBL28444425 | 0.87 | SIRT5 (0.38) | KLK7FURINSIRT1SIRT5SIRT2 | |
| SCHEMBL28631982 | 0.85 | SIRT5 (0.44) | SIRT1SIRT5SIRT2SIRT3 | |
| SCHEMBL28631983 | 0.85 | SIRT5 (0.44) | SIRT1SIRT5SIRT2SIRT3 | |
| SCHEMBL22702649 | 0.85 | KLK7 (0.37) | KLK7FURINSIRT1CASP3SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136076-A | MCL-1 inhibitor antibody drug conjugates and methods of use | 诺华股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-116761635-A | BCL-XL inhibitor antibody drug conjugates and methods of use thereof | 诺华股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-114728077-A | MCL-1 inhibitor antibody-drug conjugates and methods of use | 诺华股份有限公司 | 2022-07-08 | — | — | CN | disclosed |