Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 17/20 | 0.39 |
| ▸ | LCK | P06239 | 5/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.31 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.30 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25176442 | 0.99 | PTK6 (0.40) | PTK6LCKAURKBMAPKAPK5AURKA | |
| SCHEMBL24112330 | 0.96 | PTK6 (0.39) | PTK6LCKAURKBMAPKAPK5AURKA | |
| SCHEMBL22123725 | 0.92 | PTK6 (0.47) | PTK6LCKAURKB | |
| SCHEMBL30171867 | 0.92 | PTK6 (0.47) | PTK6LCKAURKB | |
| SCHEMBL25450726 | 0.89 | PTK6 (0.38) | PTK6LCKAURKBMAPKAPK5 | |
| SCHEMBL28982185 | 0.88 | PTK6 (0.39) | PTK6LCKEGFR | |
| Trifluoroacetic Acid SCHEMBL30386113 | 0.88 | PTK6 (0.39) | PTK6LCKAURKBMAPKAPK5AURKA | |
| SCHEMBL24112356 | 0.88 | PTK6 (0.38) | PTK6LCKAURKB | |
| SCHEMBL30402918 | 0.88 | PTK6 (0.39) | PTK6LCKEGFR | |
| Trifluoroacetic Acid SCHEMBL28982207 | 0.86 | PTK6 (0.36) | PTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161931-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2026-02-18 | — | — | EP | claimed |
| EP-4161931-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |
| CN-115916784-A | Novel imidazopyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-04-04 | — | — | CN | disclosed |