SCHEMBL28984286

SCHEMBL28984286

COc1cccc(C(=O)C=CC2=C(O)CC(O)(OC)C=C2)c1OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
NR1H4 Q96RI1 1/20 0.41
AR P10275 1/20 0.40
MAOB P27338 1/20 0.40
TUBB1 Q9H4B7 3/20 0.40
NFE2L2 Q16236 1/20 0.38
CYP1A1 P04798 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP1B1 Q16678 1/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38
TUBA4A P68366 1/20 0.38
TUBB4B P68371 1/20 0.38
TUBB3 Q13509 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6534548 0.78 MAPT (0.43) CYP3A4ALDH1A1LMNAMAPTMAOB
SCHEMBL4864045 0.71 NFE2L2 (0.72) ABCG2ALDH1A1LMNAMAPTNR1H4
SCHEMBL5313681 0.70 NR1H4 (0.64) MAPTNR1H4ARMAOBNFE2L2
SCHEMBL7199009 0.70 ABCG2 (0.51) CYP3A4ABCG2MAPTNR1H4AR
SCHEMBL7188988 0.69 CYP3A4 (0.42) CYP3A4ABCG2ALDH1A1LMNAMAPT
SCHEMBL8146116 0.69 ABCG2 (0.69) CYP3A4ABCG2LMNANR1H4AR
SCHEMBL6635025 0.66 NPC1 (0.50) CYP3A4ABCG2ALDH1A1MAPTNFE2L2
SCHEMBL7802805 0.66 CYP3A4 (0.49) CYP3A4ABCG2ALDH1A1LMNAMAPT
SCHEMBL7190596 0.65 ALOX5 (0.55) CYP3A4ABCG2ALDH1A1LMNAMAPT
SCHEMBL7188164 0.65 PDE4A (0.70) CYP3A4ABCG2ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115770270-A Daoluotong and its use method 朱亚琼 2023-03-10 CN disclosed