SCHEMBL4864045

SCHEMBL4864045

COc1cccc(/C=C/C(=O)c2cccc(OC)c2OC)c1OC

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 2/20 0.72
ALOX5 P09917 2/20 0.67
CYP1A1 P04798 1/20 0.67
CYP1A2 P05177 1/20 0.67
CYP2D6 P10635 1/20 0.67
MAOB P27338 3/20 0.64
AR P10275 1/20 0.61
NR1H4 Q96RI1 1/20 0.60
TRPM8 Q7Z2W7 1/20 0.59
ALDH1A1 P00352 2/20 0.59
LMNA P02545 2/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
KDM4E B2RXH2 1/20 0.59
MEN1 O00255 1/20 0.59
POLB P06746 1/20 0.59
GAA P10253 1/20 0.59
MAPT P10636 1/20 0.59
PKM P14618 1/20 0.59
HPGD P15428 1/20 0.59
HTT P42858 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1764951 0.93 NFE2L2 (0.70) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL8146116 0.91 ABCG2 (0.69) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL5313681 0.90 NR1H4 (0.64) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL5084423 0.89 MAOB (0.80) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL5084427 0.89 MAOB (0.80) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL7096835 0.88 NFE2L2 (0.63) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL7190596 0.86 ALOX5 (0.55) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL7190604 0.86 ALOX5 (0.55) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL19183189 0.86 NFE2L2 (0.74) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6
SCHEMBL19183192 0.86 NFE2L2 (0.74) NFE2L2ALOX5CYP1A1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2025-08-14 US disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20240285592-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2024-08-29 US disclosed
US-11951099-B2 Methods for treating plasma cell neoplasm with human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2024-04-09 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2022-05-19 US disclosed
US-11266634-B2 Methods for treating melanoma with human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2022-03-08 US disclosed
CN-113956226-A Method for synthesizing carvachin 南京科技职业学院 2022-01-21 CN disclosed
US-20200383958-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2020-12-10 US disclosed
US-10751330-B2 Human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2020-08-25 US disclosed
US-20180078535-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2018-03-22 US disclosed
US-9907786-B2 Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof IONS PHARMACEUTICAL S.À R.L. (LU) 2018-03-06 US disclosed
US-20170216222-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-08-03 US disclosed
US-20170105975-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-04-20 US disclosed
US-20170105976-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF Ions Pharmaceutical S.à r.I. (LU) 2017-04-20 US disclosed
US-20170042865-A1 THERAPEUTIC COMPOSITIONS CONTAINING CURCUMIN, HARMINE, AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-02-16 US disclosed
US-20170042867-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-02-16 US disclosed
US-20170042866-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF IONS PHARMACEUTICAL S.À R.L. (LU) 2017-02-16 US disclosed
US-7432303-B2 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states Bowen, J. Phillip (US) 2008-10-07 US disclosed
US-20050148599-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2005-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11266634-B2 Methods for treating melanoma with human therapeutic agents HNMT, INMT, TYR NFE2L2 612/4885ALOX5 1399/4885CYP1A1 3556/4885
US-20170216222-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT NFE2L2 1139/4885ALOX5 1046/4885CYP1A1 1827/4885
US-11951099-B2 Methods for treating plasma cell neoplasm with human therapeutic agents MCL1, CD44, INMT NFE2L2 1029/4885ALOX5 566/4885CYP1A1 3865/4885
US-20180078535-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT NFE2L2 1139/4885ALOX5 1046/4885CYP1A1 1827/4885
US-10751330-B2 Human therapeutic agents INMT, HNMT, HASPIN NFE2L2 832/4885ALOX5 1897/4885CYP1A1 2202/4885
US-20240285592-A1 HUMAN THERAPEUTIC AGENTS INMT, NLN, MYC NFE2L2 844/4885ALOX5 1696/4885CYP1A1 3142/4885
US-20170042865-A1 THERAPEUTIC COMPOSITIONS CONTAINING CURCUMIN, HARMINE, AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, CPT1A NFE2L2 1281/4885ALOX5 1206/4885CYP1A1 1680/4885
US-20170105976-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT NFE2L2 1139/4885ALOX5 1046/4885CYP1A1 1827/4885
US-20170042867-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT NFE2L2 1139/4885ALOX5 1046/4885CYP1A1 1827/4885
US-20050148599-A1 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states FLT1, VEGFA, FLT4 NFE2L2 372/4885ALOX5 2036/4885CYP1A1 625/4885
US-20170042866-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT NFE2L2 1139/4885ALOX5 1046/4885CYP1A1 1827/4885
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN NFE2L2 832/4885ALOX5 1897/4885CYP1A1 2202/4885
US-20170105975-A1 THERAPEUTIC COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF INMT, HNMT, COMT NFE2L2 1139/4885ALOX5 1046/4885CYP1A1 1827/4885
US-20200383958-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN NFE2L2 832/4885ALOX5 1897/4885CYP1A1 2202/4885
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS HASPIN, TIPARP, SHARPIN NFE2L2 932/4885ALOX5 2214/4885CYP1A1 4150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.