Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 14/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984535 | 0.90 | PTGDR2 (0.53) | MAPTTHRBALDH1A1ENPP2 | |
| SCHEMBL30130256 | 0.89 | P2RX3 (0.52) | MAPTTHRBALDH1A1ENPP2PPARG | |
| SCHEMBL31119362 | 0.89 | P2RX3 (0.52) | MAPTTHRBALDH1A1ENPP2PPARG | |
| SCHEMBL24914448 | 0.88 | MAPT (0.59) | MAPTTHRBALDH1A1KAT2B | |
| SCHEMBL30130099 | 0.88 | MAPT (0.59) | MAPTTHRBALDH1A1KAT2B | |
| SCHEMBL24914717 | 0.88 | MAPT (0.59) | MAPTTHRBALDH1A1KAT2B | |
| SCHEMBL28984484 | 0.88 | ENPP2 (0.50) | MAPTENPP2 | |
| SCHEMBL28984530 | 0.88 | ENPP2 (0.50) | ENPP2 | |
| SCHEMBL28984477 | 0.87 | ENPP2 (0.61) | ENPP2 | |
| SCHEMBL28984478 | 0.86 | ENPP2 (0.63) | MAPTENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611896-A | Compound containing tetralone or tetrahydropyridopyrimidone skeleton and preparation method and pharmaceutical application thereof | 中国药科大学 | 2023-01-17 | — | — | CN | disclosed |